The ERK-MAPK Pathway Regulates Longevity through SKN-1 and Insulin-like Signaling in Caenorhabditis elegans

It has not been determined yet whether the ERK-MAPK pathway regulates longevity of metazoans. Here, we show that the Caenorhabditis elegans ERK cascade promotes longevity through the two longevity-promoting transcription factors, SKN-1 and DAF-16. We find that RNAi of three genes, which constitute t...

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Bibliographic Details
Main Authors: Okuyama, Tetsuya, Inoue, Hideki, Ookuma, Sadatsugu, Satoh, Takayuki, Kano, Kei, Honjoh, Sakiko, Hisamoto, Naoki, Matsumoto, Kunihiro, Nishida, Eisuke
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943277/
https://ncbi.nlm.nih.gov/pubmed/20624915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146274
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