Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

Many neurodegenerative diseases exhibit protein accumulation and increased oxidative stress. Therapeutic strategies include clearing aggregate-prone proteins by enhancing autophagy or decreasing oxidative stress with antioxidants. Many autophagy-inducing stimuli increase reactive oxygen species (ROS...

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Main Authors: Underwood, Benjamin R., Imarisio, Sara, Fleming, Angeleen, Rose, Claudia, Krishna, Gauri, Heard, Phoebe, Quick, Marie, Korolchuk, Viktor I., Renna, Maurizio, Sarkar, Sovan, García-Arencibia, Moisés, O'Kane, Cahir J., Murphy, Michael P., Rubinsztein, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916709/
https://ncbi.nlm.nih.gov/pubmed/20566712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq253
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