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Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
Many neurodegenerative diseases exhibit protein accumulation and increased oxidative stress. Therapeutic strategies include clearing aggregate-prone proteins by enhancing autophagy or decreasing oxidative stress with antioxidants. Many autophagy-inducing stimuli increase reactive oxygen species (ROS...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916709/ https://ncbi.nlm.nih.gov/pubmed/20566712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq253 |
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