myc maintains embryonic stem cell pluripotency and self-renewal

While endogenous Myc (c-myc) and Mycn (N-myc) have been reported to be separately dispensable for murine embryonic stem cell (mESC) function, myc greatly enhances induced pluripotent stem (iPS) cell formation and overexpressed c-myc confers LIF-independence upon mESC. To address the role of myc gene...

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Autors principals: Varlakhanova, Natalia V., Cotterman, Rebecca F., deVries, Wilhelmine N., Morgan, Judy, Donahue, Leah Rae, Murray, Stephen, Knowles, Barbara B., Knoepfler, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916696/
https://ncbi.nlm.nih.gov/pubmed/20537458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2010.05.001
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