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REST/NRSF Maintains Self-Renewal and Pluripotency of Embryonic Stem Cells

The neuronal repressor REST/NRSF is expressed at high levels in mouse embryonic stem (mES) cells1, but its role in these cells has not been understood. Here we show that REST maintains self-renewal and pluripotency in mES cells through suppression of microRNA (miR)-21. We found that, as with known s...

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Hlavní autoři: Singh, Sanjay K., Kagalwala, Mohamedi N., Parker-Thornburg, Jan, Adams, Henry, Majumder, Sadhan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830094/
https://ncbi.nlm.nih.gov/pubmed/18362916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06863
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