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REST/NRSF Maintains Self-Renewal and Pluripotency of Embryonic Stem Cells
The neuronal repressor REST/NRSF is expressed at high levels in mouse embryonic stem (mES) cells1, but its role in these cells has not been understood. Here we show that REST maintains self-renewal and pluripotency in mES cells through suppression of microRNA (miR)-21. We found that, as with known s...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830094/ https://ncbi.nlm.nih.gov/pubmed/18362916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06863 |
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