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Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type 1α2-Expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion

IGF-I acts through endocrine and local, autocrine/paracrine routes. Disruption of both endocrine and local IGF-I action leads to neonatal lethality and impaired growth in various tissues including bone; however, the severity of growth and skeletal phenotype caused by disruption of endocrine IGF-I ac...

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Bibliografski detalji
Glavni autori: Govoni, Kristen E., Wergedal, Jon E., Florin, Lore, Angel, Peter, Baylink, David J., Mohan, Subburaman
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916650/
https://ncbi.nlm.nih.gov/pubmed/17717052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0608
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