The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression†,‡

[Image: see text] The mixed lineage leukemia (MLL) gene plays a critical role in epigenetic regulation of gene expression and is a frequent target of chromosomal translocations leading to leukemia. MLL plant homeodomain 3 (PHD3) is lost in all MLL translocation products, and reinsertion of PHD3 into...

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Bibliografski detalji
Glavni autori: Park, Sangho, Osmers, Ute, Raman, Gayathree, Schwantes, Rebecca H., Diaz, Manuel O., Bushweller, John H.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2010
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916634/
https://ncbi.nlm.nih.gov/pubmed/20677832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1009387
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