Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression

The MLL1 gene is a frequent target for recurrent chromosomal translocations, resulting in transformation of hematopoietic precursors into leukemia stem cells. Here, we report on structure-function studies that elucidate molecular events in MLL1 binding of histone H3K4me3/2 marks and recruitment of t...

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Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Wang, Zhanxin, Song, Jikui, Milne, Thomas A., Wang, Gang G., Li, Haitao, Allis, C. David, Patel, Dinshaw J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690531/
https://ncbi.nlm.nih.gov/pubmed/20541251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.05.016
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