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The Localization of APOBEC3H Variants in HIV-1 Virions Determines Their Antiviral Activity

Several members of the human APOBEC3 family of cytidine deaminases can potently restrict retroviruses such as HIV-1. The single-domain APOBEC3H (A3H) is encoded by four haplotypes, of which only A3H haplotype II-RDD (hapII-RDD) restricts HIV-1 efficiently. The goal of this study was to elucidate the...

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Detalhes bibliográficos
Main Authors: Ooms, Marcel, Majdak, Susan, Seibert, Christopher W., Harari, Ariana, Simon, Viviana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916534/
https://ncbi.nlm.nih.gov/pubmed/20519396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00754-10
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