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The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

Epac1 (exchange protein directly activated by cyclic AMP [cAMP]) couples intracellular cAMP to the activation of Rap1, a Ras family GTPase that regulates cell adhesion, proliferation, and differentiation. Using mass spectrometry, we identified the small G protein Ran and Ran binding protein 2 (RanBP...

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Autors principals: Liu, Chang, Takahashi, Maho, Li, Yanping, Dillon, Tara J., Kaech, Stefanie, Stork, Philip J. S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916442/
https://ncbi.nlm.nih.gov/pubmed/20547757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00242-10
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