Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a

The hepatitis C virus (HCV) subgenomic replicon is the primary tool for evaluating the activity of anti-HCV compounds in drug discovery research. Despite the prevalence of HCV genotype 1a (∼70% of U.S. HCV patients), few genotype 1a reporter replicon cell lines have been described; this is presumabl...

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Main Authors: Robinson, Margaret, Yang, Huiling, Sun, Siu-Chi, Peng, Betty, Tian, Yang, Pagratis, Nikos, Greenstein, Andrew E., Delaney, William E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916306/
https://ncbi.nlm.nih.gov/pubmed/20516274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00289-10
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