Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing

The establishment of an aerosol challenge model in nonhuman primates (NHPs) for the testing of vaccines against Mycobacterium tuberculosis would assist the global effort to optimize novel vaccination strategies. The endpoints used in preclinical challenge studies to identify measures of disease burd...

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Hauptverfasser: Sharpe, S. A., McShane, H., Dennis, M. J., Basaraba, R. J., Gleeson, F., Hall, G., McIntyre, A., Gooch, K., Clark, S., Beveridge, N. E. R., Nuth, E., White, A., Marriott, A., Dowall, S., Hill, A. V. S., Williams, A., Marsh, P. D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Vaccine Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916246/
https://ncbi.nlm.nih.gov/pubmed/20534795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00079-10
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