High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals within 10 weeks of challenge,...

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Udgivet i:Sci Rep
Main Authors: Sibley, Laura, White, Andrew D., Gooch, Karen E., Stevens, Lisa M., Tanner, Rachel, Jacobs, Ashley, Daykin-Pont, Owen, Gleeson, Fergus, McIntyre, Anthony, Basaraba, Randall, Clark, Simon, Hall, Graham, Pearson, Geoff, Rayner, Emma, McShane, Helen, Williams, Ann, Dennis, Mike, Marsh, Philip D., Sharpe, Sally
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192909/
https://ncbi.nlm.nih.gov/pubmed/34112845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90913-0
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