MDM2 Polymorphism Increases Susceptibility to Childhood Acute Myeloid Leukemia: A Report from the Children’s Oncology Group

BACKGROUND: The variant polymorphism in the gene MDM2, SNP309, leads to increased level of mdm2 protein and subsequent downregulation of p53 tumor suppressor pathway. Presence of this single nucleotide polymorphism (SNP) has been associated with earlier tumorigenesis in patients with Li-Fraumeni syn...

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Main Authors: Phillips, Christine L, Gerbing, Robert, Alonzo, Todd, Perentesis, John P, Harley, Isaac TW, Meshinchi, Soheil, Bhatla, Deepika, Radloff, Gretchen, Davies, Stella M
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915901/
https://ncbi.nlm.nih.gov/pubmed/20582981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22519
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