MDM2 Polymorphism Increases Susceptibility to Childhood Acute Myeloid Leukemia: A Report from the Children’s Oncology Group

BACKGROUND: The variant polymorphism in the gene MDM2, SNP309, leads to increased level of mdm2 protein and subsequent downregulation of p53 tumor suppressor pathway. Presence of this single nucleotide polymorphism (SNP) has been associated with earlier tumorigenesis in patients with Li-Fraumeni syn...

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Bibliographic Details
Main Authors: Phillips, Christine L, Gerbing, Robert, Alonzo, Todd, Perentesis, John P, Harley, Isaac TW, Meshinchi, Soheil, Bhatla, Deepika, Radloff, Gretchen, Davies, Stella M
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915901/
https://ncbi.nlm.nih.gov/pubmed/20582981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22519
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