Cytidine Deaminase Genotype and Toxicity of Cytosine Arabinoside Therapy in Children with Acute Myeloid Leukemia

Cytosine arabinoside (ara-C) is irreversibly deaminated by cytidine deaminase (CDD) to a nontoxic metabolite. A common polymorphism, A79C, in CDD changes a lysine residue to glutamine resulting in decreased enzyme activity. We determined CDD A79C genotypes for 457 children with AML treated on CCG 29...

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Autores principales: Bhatla, Deepika, Gerbing, Robert B, Alonzo, Todd A., Conner, Heather, Ross, Julie A, Meshinchi, Soheil, Zhai, Xiaowen, Zamzow, Tiffany, Mehta, Parinda A, Geiger, Hartmut, Perentesis, John, Davies, Stella M
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083240/
https://ncbi.nlm.nih.gov/pubmed/19036079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2008.07461.x
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