MDM2 Polymorphism Increases Susceptibility to Childhood Acute Myeloid Leukemia: A Report from the Children’s Oncology Group

BACKGROUND: The variant polymorphism in the gene MDM2, SNP309, leads to increased level of mdm2 protein and subsequent downregulation of p53 tumor suppressor pathway. Presence of this single nucleotide polymorphism (SNP) has been associated with earlier tumorigenesis in patients with Li-Fraumeni syn...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Phillips, Christine L, Gerbing, Robert, Alonzo, Todd, Perentesis, John P, Harley, Isaac TW, Meshinchi, Soheil, Bhatla, Deepika, Radloff, Gretchen, Davies, Stella M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915901/
https://ncbi.nlm.nih.gov/pubmed/20582981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22519
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