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MDM2 Polymorphism Increases Susceptibility to Childhood Acute Myeloid Leukemia: A Report from the Children’s Oncology Group
BACKGROUND: The variant polymorphism in the gene MDM2, SNP309, leads to increased level of mdm2 protein and subsequent downregulation of p53 tumor suppressor pathway. Presence of this single nucleotide polymorphism (SNP) has been associated with earlier tumorigenesis in patients with Li-Fraumeni syn...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915901/ https://ncbi.nlm.nih.gov/pubmed/20582981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22519 |
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