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Kinetics of Amyloid β monomer to oligomer exchange by NMR Relaxation

Recent studies implicating non-fibrillar oligomers of the amyloid β (Aβ) peptide as the primary toxic species in Alzheimer’s disease have made Aβ oligomers the subject of intense study. Detailed structural and kinetic characterization of these states, however, has been difficult. Here we use NMR rel...

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Bibliographic Details
Main Authors: Fawzi, Nicolas L., Ying, Jinfa, Torchia, Dennis A., Clore, G. Marius
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915839/
https://ncbi.nlm.nih.gov/pubmed/20604554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1048253
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