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Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR

The mechanism whereby the prototypical chaperonin GroEL performs work on substrate proteins has not yet been fully elucidated, hindered by lack of detailed structural and dynamic information on the bound substrate. Previous investigations have produced conflicting reports on the state of GroEL-bound...

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Main Authors: Libich, David S., Fawzi, Nicolas L., Ying, Jinfa, Clore, G. Marius
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710837/
https://ncbi.nlm.nih.gov/pubmed/23798407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305715110
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