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Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR
The mechanism whereby the prototypical chaperonin GroEL performs work on substrate proteins has not yet been fully elucidated, hindered by lack of detailed structural and dynamic information on the bound substrate. Previous investigations have produced conflicting reports on the state of GroEL-bound...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710837/ https://ncbi.nlm.nih.gov/pubmed/23798407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305715110 |
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