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Kinetics of Amyloid β monomer to oligomer exchange by NMR Relaxation

Recent studies implicating non-fibrillar oligomers of the amyloid β (Aβ) peptide as the primary toxic species in Alzheimer’s disease have made Aβ oligomers the subject of intense study. Detailed structural and kinetic characterization of these states, however, has been difficult. Here we use NMR rel...

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Detalhes bibliográficos
Main Authors: Fawzi, Nicolas L., Ying, Jinfa, Torchia, Dennis A., Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915839/
https://ncbi.nlm.nih.gov/pubmed/20604554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1048253
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