Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway

12/15-lipoxygenase (12/15-LOX) contributes to acute neuronal injury and edema formation in mouse models of middle cerebral artery occlusion (MCAO). The apoptosis-inducing factor (AIF) is implicated in caspase-independent forms of apoptosis, and has been linked to ischemic neuronal cell death. We sho...

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Autori principali: Pallast, Stefanie, Arai, Ken, Pekcec, Anton, Yigitkanli, Kazim, Yu, Zhanyang, Wang, Xiaoying, Lo, Eng H, van Leyen, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915762/
https://ncbi.nlm.nih.gov/pubmed/20068575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.281
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