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Rac1-mediated Mitochondrial H(2)O(2) Generation Regulates MMP-9 Gene Expression in Macrophages via Inhibition of SP-1 and AP-1
Aberrant matrix deposition is a hallmark of pulmonary fibrosis and is characterized by an imbalance between matrix deposition and degradation. We have previously shown that mice harboring a conditional deletion of the GTP-binding protein, Rac1, in macrophages are protected from asbestos-induced pulm...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915742/ https://ncbi.nlm.nih.gov/pubmed/20529870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099655 |
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