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SP-1 regulation of MMP-9 expression requires serine-586 in the PEST domain
Rac1, a small GTPase, regulates macrophage matrix metalloproteinase-9 (MMP-9) in an ERK- and SP-1-dependent manner. SP-1 contains a PEST domain that may modulate protein stability. We hypothesize that T578, S586, and/or S587 in the PEST domain are required for SP-1 stability and MMP-9 expression sec...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663053/ https://ncbi.nlm.nih.gov/pubmed/22519702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120053 |
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