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Mitochondrial Cu,Zn-Superoxide Dismutase Mediates Pulmonary Fibrosis by Augmenting H(2)O(2) Generation

The release of H(2)O(2) from alveolar macrophages has been linked to the development of pulmonary fibrosis, but little is known about its source or mechanism of production. We found that alveolar macrophages from asbestosis patients spontaneously produce high levels of H(2)O(2) and have high express...

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Autors principals: He, Chao, Murthy, Shubha, McCormick, Michael L., Spitz, Douglas R., Ryan, Alan J., Carter, A. Brent
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083152/
https://ncbi.nlm.nih.gov/pubmed/21393238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187377
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