Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis

The generation of reactive oxygen species, particularly H(2)O(2), from alveolar macrophages is causally related to the development of pulmonary fibrosis. Rac1, a small GTPase, is known to increase mitochondrial H(2)O(2) generation in macrophages; however, the mechanism by which this occurs is not kn...

Full description

Saved in:
Bibliographic Details
Main Authors: Osborn-Heaford, Heather L., Ryan, Alan J., Murthy, Shubha, Racila, Ana-Monica, He, Chao, Sieren, Jessica C., Spitz, Douglas R., Carter, A. Brent
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270985/
https://ncbi.nlm.nih.gov/pubmed/22157762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308387
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items