Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis

The generation of reactive oxygen species, particularly H(2)O(2), from alveolar macrophages is causally related to the development of pulmonary fibrosis. Rac1, a small GTPase, is known to increase mitochondrial H(2)O(2) generation in macrophages; however, the mechanism by which this occurs is not kn...

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Hlavní autoři: Osborn-Heaford, Heather L., Ryan, Alan J., Murthy, Shubha, Racila, Ana-Monica, He, Chao, Sieren, Jessica C., Spitz, Douglas R., Carter, A. Brent
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270985/
https://ncbi.nlm.nih.gov/pubmed/22157762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308387
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