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DNAJB6 Induces Degradation of β-Catenin and Causes Partial Reversal of Mesenchymal Phenotype

We showed that expression of MRJ (DNAJB6) protein is lost in invasive ductal carcinoma, and restoration of MRJ(L) restricts malignant behavior of breast cancer and melanoma cells. However, the signaling pathways influenced by MRJ(L) are largely unknown. Our observations revealed that MRJ(L) expressi...

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Detalhes bibliográficos
Main Authors: Mitra, Aparna, Menezes, Mitchell E., Shevde, Lalita A., Samant, Rajeev S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915705/
https://ncbi.nlm.nih.gov/pubmed/20522561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094847
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