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DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. We have previously reported an important involvement of DNAJB6, a member of heatshock protein 40 (HSP40) family, in negatively impacting tumor growth. The current s...

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Bibliographische Detailangaben
Hauptverfasser: Mitra, A, Menezes, ME, Pannell, LK, Mulekar, MS, Honkanen, RE, Shevde, LA, Samant, RS
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717376/
https://ncbi.nlm.nih.gov/pubmed/22266849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.623
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