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DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin
Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. We have previously reported an important involvement of DNAJB6, a member of heatshock protein 40 (HSP40) family, in negatively impacting tumor growth. The current s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3717376/ https://ncbi.nlm.nih.gov/pubmed/22266849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.623 |
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