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Evaluation of BACE1 Silencing in Cellular Models
Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) peptides, identified in amyloid plaques of Alzheimer's disease (AD) brains. Its downregulation results in decreasing secretion of Aβ. Thus, BACE1 silencing by RNAi represents possible strategy for...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
SAGE-Hindawi Access to Research
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915613/ https://ncbi.nlm.nih.gov/pubmed/20721293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2009/257403 |
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