Evaluation of BACE1 Silencing in Cellular Models

Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) peptides, identified in amyloid plaques of Alzheimer's disease (AD) brains. Its downregulation results in decreasing secretion of Aβ. Thus, BACE1 silencing by RNAi represents possible strategy for...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sierant, Malgorzata, Kubiak, Katarzyna, Kazmierczak-Baranska, Julia, Warashina, Masaki, Kuwabara, Tomoko, Nawrot, Barbara
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: SAGE-Hindawi Access to Research 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915613/
https://ncbi.nlm.nih.gov/pubmed/20721293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2009/257403
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