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Genetic reduction of lipoic acid synthase expression modestly increases atherosclerosis in male, but not in female, apolipoprotein E deficient mice

OBJECTIVES: To evaluate the effects of a genetic reduction of Lias gene expression on atherosclerosis development. METHODS AND RESULTS: Heterozygous knockout mice for the lipoid acid synthase gene (Lias(+/−)) were crossed with apolipoprotein E–deficient (ApoE(−/−)) mice, and the plaque size in aorti...

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Huvudupphovsmän: Yi, Xianwen, Xu, Longquan, Kim, Kuikwon, Kim, Hyung-Suk, Maeda, Nobuyo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914155/
https://ncbi.nlm.nih.gov/pubmed/20347443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2010.03.009
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