Chk2*1100delC Acts in Synergy with the Ron Receptor Tyrosine Kinase to Accelerate Mammary Tumorigenesis in Mice

The CHEK2 (Chk2 in mice) polymorphic variant, CHEK2*1100delC, leads to genomic instability and is associated with an increased risk for breast cancer. The Ron receptor tyrosine kinase is overexpressed in a large fraction of human breast cancers. Here, we asked whether the low penetrance Chk2*1100del...

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Autori principali: Meyer, Sara E., Peace, Belinda E., Bahassi, El Mustapha, Kavanaugh, Gina M., Wagh, Purnima K., Robbins, Susan B., Yin, Moying, Wells, Susanne I., Zinser, Glendon M., Stambrook, Peter J., Waltz, Susan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914152/
https://ncbi.nlm.nih.gov/pubmed/20434834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.04.011
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