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Uptake of pramipexole by human organic cation transporters
Pramipexole is a hydrophilic, weakly basic drug, but exhibits high oral bioavailability in humans (> 90%). In rats, rOct1 and rOct2 contribute towards pramipexole excretion into urine. The objective of this study was to assess whether pramipexole is a substrate for human OCT1-3. In vitro uptake s...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2914150/ https://ncbi.nlm.nih.gov/pubmed/20496886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100036b |
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