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Human mutation rate associated with DNA replication timing
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating reg...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2914101/ https://ncbi.nlm.nih.gov/pubmed/19287383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.363 |
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