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Unactivated PKR exists in an open conformation capable of binding nucleotides
The dsRNA-activated protein kinase, PKR, plays a pivotal role in the cellular antiviral response. PKR contains an N-terminal dsRNA binding domain (dsRBD) and a C-terminal kinase domain. An autoinhibition model has been proposed in which latent PKR exists in a closed conformation where the substrate...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913708/ https://ncbi.nlm.nih.gov/pubmed/16866353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060567d |
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