E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin α(L)β(2)-mediated slow leukocyte rolling

In inflamed venules, neutrophils rolling on E-selectin induce integrin α(L)β(2)-dependent slow rolling on intercellular adhesion molecule-1 by activating Src family kinases (SFKs), DAP12 and Fc receptor-γ (FcRγ), spleen tyrosine kinase (Syk), and p38. E-selectin signaling cooperates with chemokine s...

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Detalhes bibliográficos
Main Authors: Yago, Tadayuki, Shao, Bojing, Miner, Jonathan J., Yao, Longbiao, Klopocki, Arkadiusz G., Maeda, Kenichiro, Coggeshall, K. Mark, McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913455/
https://ncbi.nlm.nih.gov/pubmed/20299514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-259556
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