Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells

We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we have analyzed the mechanisms underlying these phenome...

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Hlavní autoři: Koesters, Robert, Kaissling, Brigitte, LeHir, Michel, Picard, Nicolas, Theilig, Franziska, Gebhardt, Rolf, Glick, Adam B., Hähnel, Brunhilde, Hosser, Hiltraud, Gröne, Hermann-Josef, Kriz, Wilhelm
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913362/
https://ncbi.nlm.nih.gov/pubmed/20616344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091012
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