Structural analysis of how podocytes detach from the glomerular basement membrane under hypertrophic stress

Podocytes are lost by detachment from the GBM as viable cells; details are largely unknown. We studied this process in the rat after growth stimulation with FGF-2. Endothelial and mesangial cells responded by hyperplasia, podocytes underwent hypertrophy, but, in the long run, developed various chang...

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Detalhes bibliográficos
Main Authors: Wilhelm eKriz, Brunhilde eHähnel, Hiltraud eHosser, Sigrid eRösener, Rüdiger eWaldherr
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-12-01
Colecção:Frontiers in Endocrinology
Assuntos:
Podocyte hypertrophy
Foot process effacement
Sealing of filtration slits
Pseudocysts
Podocyte detachment
Crescents
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00207/full
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