Oxidation of multiple methionine residues impairs rapid sodium channel inactivation

Reactive oxygen species (ROS) readily oxidize the sulfur-containing amino acids cysteine and methionine (Met). The impact of Met oxidation on the fast inactivation of the skeletal muscle sodium channel Na(V)1.4 expressed in human embryonic kidney cells was studied by applying the Met-preferring oxid...

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Bibliografiske detaljer
Main Authors: Kassmann, Mario, Hansel, Alfred, Leipold, Enrico, Birkenbeil, Jan, Lu, Song-Qing, Hoshi, Toshinori, Heinemann, Stefan H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913308/
https://ncbi.nlm.nih.gov/pubmed/18369661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0477-6
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