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Three methionine residues located within the regulator of conductance for K(+) (RCK) domains confer oxidative sensitivity to large-conductance Ca(2)(+)-activated K(+) channels
Methionine-directed oxidation of the human Slo1 potassium channel (hSlo1) shifts the half-activation voltage by −30 mV and markedly slows channel deactivation at low concentrations of intracellular Ca(2)(+) ([Ca(2)(+)](i)). We demonstrate here that the contemporaneous mutation of M536, M712 and M739...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Science Inc
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1796801/ https://ncbi.nlm.nih.gov/pubmed/16396928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.101089 |
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