Large-conductance Ca(2+)- and voltage-gated K(+) channels form and break interactions with membrane lipids during each gating cycle

Membrane depolarization and intracellular Ca(2+) promote activation of the large-conductance Ca(2+)- and voltage-gated (Slo1) big potassium (BK) channel. We examined the physical interactions that stabilize the closed and open conformations of the ion conduction gate of the human Slo1 channel using...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tian, Yutao, Heinemann, Stefan H., Hoshi, Toshinori
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486743/
https://ncbi.nlm.nih.gov/pubmed/30967508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901381116
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