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Free Energy Calculations Reveal Rotating-Ratchet Mechanism for DNA Supercoil Relaxation by Topoisomerase IB and its Inhibition
Topoisomerases maintain the proper topological state of DNA. Human topoisomerase I removes DNA supercoils by clamping a duplex DNA segment, nicking one strand at a phosphodiester bond, covalently attaching to the 3′ end of the nick, and allowing the DNA downstream of the cut to rotate around the int...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913206/ https://ncbi.nlm.nih.gov/pubmed/20682265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.077 |
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