A Multiscale Dynamic Model of DNA Supercoil Relaxation by Topoisomerase IB

In this study, we report what we believe to be the first multiscale simulation of the dynamic relaxation of DNA supercoils by human topoisomerase IB (topo IB). We leverage our previous molecular dynamics calculations of the free energy landscape describing the interaction between a short DNA fragmen...

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Autors principals: Lillian, Todd D., Taranova, Maryna, Wereszczynski, Jeff, Andricioaei, Ioan, Perkins, N.C.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
Matèries:
Nucleic Acid
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077681/
https://ncbi.nlm.nih.gov/pubmed/21504738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.03.003
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