Yüklüyor......
Free Energy Calculations Reveal Rotating-Ratchet Mechanism for DNA Supercoil Relaxation by Topoisomerase IB and its Inhibition
Topoisomerases maintain the proper topological state of DNA. Human topoisomerase I removes DNA supercoils by clamping a duplex DNA segment, nicking one strand at a phosphodiester bond, covalently attaching to the 3′ end of the nick, and allowing the DNA downstream of the cut to rotate around the int...
Kaydedildi:
| Asıl Yazarlar: | , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Biophysical Society
2010
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913206/ https://ncbi.nlm.nih.gov/pubmed/20682265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.077 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|