Allosteric Effects of the Anti-Psychotic Drug Trifluoperazine on the Energetics of Calcium Binding by Calmodulin

Trifluoperazine (TFP; Stelazine™) is an antagonist of calmodulin (CaM), an essential regulator of calcium-dependent signal transduction. Reports differ regarding whether, or where, TFP binds to apo CaM. Three crystallographic structures (1CTR, 1A29, 1LIN) show TFP bound to (Ca(2+))(4)-CaM in ratios...

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Hlavní autoři: Feldkamp, Michael D., O'Donnell, Susan E., Yu, Liping, Shea, Madeline A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913171/
https://ncbi.nlm.nih.gov/pubmed/20544963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22739
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