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Recognition of β–Calcineurin by the Domains of Calmodulin: Thermodynamic and Structural Evidence for Distinct Roles
Calcineurin (CaN, PP2B, PPP3), a heterodimeric Ca(2+)-calmodulin-dependent Ser/Thr phosphatase, regulates swimming in Paramecia, stress responses in yeast, and T-cell activation and cardiac hypertrophy in humans. Calcium binding to CaN(B) (the regulatory subunit) triggers conformational change in Ca...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057930/ https://ncbi.nlm.nih.gov/pubmed/21287611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22917 |
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