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Thermodynamic Linkage Between Calmodulin Domains Binding Calcium and Contiguous Sites in the C-Terminal Tail of Ca(V)1.2

Calmodulin (CaM) binding to the intracellular C-terminal tail (CTT) of the cardiac L-type Ca(2+) channel (Ca(V)1.2) regulates Ca(2+) entry by recognizing sites that contribute to negative feedback mechanisms for channel closing. CaM associates with Ca(V)1.2 under low resting [Ca(2+)], but is poised...

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Detalhes bibliográficos
Main Authors: Evans, T. Idil Apak, Hell, Johannes, Shea, Madeline A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340011/
https://ncbi.nlm.nih.gov/pubmed/21757287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.06.007
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