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Structural and Energetic Determinants of Apo Calmodulin Binding to the IQ Motif of the Na(V)1.2 Voltage-Dependent Sodium Channel

The neuronal voltage-dependent sodium channel (Na(v)1.2), essential for generation and propagation of action potentials, is regulated by calmodulin (CaM) binding to the IQ motif in its α-subunit. A peptide (Na(v)1.2(IQp), KRKQEEVSAIVIQRAYRRYLLKQKVKK) representing the IQ motif had higher affinity for...

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Détails bibliographiques
Auteurs principaux: Feldkamp, Michael D., Yu, Liping, Shea, Madeline A.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094505/
https://ncbi.nlm.nih.gov/pubmed/21439835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.02.009
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