p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

PURPOSE: The pathogenesis of age-related macular degeneration involves impaired protein degradation in retinal pigment epithelial (RPE) cells. The ubiquitin-proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic systems in eukaryotic cells. Prior to proteolysis, h...

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Main Authors: Viiri, Johanna, Hyttinen, Juha M. T., Ryhänen, Tuomas, Rilla, Kirsi, Paimela, Tuomas, Kuusisto, Erkki, Siitonen, Ari, Urtti, Arto, Salminen, Antero, Kaarniranta, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913138/
https://ncbi.nlm.nih.gov/pubmed/20680098
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