Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

The pathogenesis of age-related macular degeneration involves chronic oxidative stress, impaired degradation of membranous discs shed from photoreceptor outer segments and accumulation of lysosomal lipofuscin in retinal pigment epithelial (RPE) cells. It has been estimated that a major part of cellu...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Ryhänen, Tuomas, Hyttinen, Juha M T, Kopitz, Jürgen, Rilla, Kirsi, Kuusisto, Erkki, Mannermaa, Eliisa, Viiri, Johanna, Holmberg, Carina I, Immonen, Ilkka, Meri, Seppo, Parkkinen, Jussi, Eskelinen, Eeva-Liisa, Uusitalo, Hannu, Salminen, Antero, Kaarniranta, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2009
Assuntos:
Cell Death
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516511/
https://ncbi.nlm.nih.gov/pubmed/19017362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00577.x
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