RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a subject of controversy. We show here that, in addition to tRNA(Asp-GTC), tRNA(Val-AAC) and tRNA(Gly-GCC) are also methylated by Dnmt2. Drosop...

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Bibliografiske detaljer
Main Authors: Schaefer, Matthias, Pollex, Tim, Hanna, Katharina, Tuorto, Francesca, Meusburger, Madeleine, Helm, Mark, Lyko, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2010
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912555/
https://ncbi.nlm.nih.gov/pubmed/20679393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.586710
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